Stem Cell Image Cytometry: Quantitative Strategies for Cell Sourcing in Musculoskeletal Tissue Engineering
Wednesday, August 1 at 12pm Eastern (U.S. & Canada)
George Muschler, MD
Director, Regenerative Medicine Laboratory
Cleveland, Ohio, USA
About the Presenter
Dr. Muschler is a nationally-recognized Cleveland Clinic Orthopaedic Surgeon who has devoted his career to advancing patient care through basic and clinical research, and quality management. As a clinician-scientist, his research laboratory focuses now on adult stem cell biology and tissue engineering, with particular interest in improving methods for harvest and processing of human stem cells and progenitors to enhance tissue regeneration and repair, design and use of quantitative assays of stem cells and progenitor cells relevant to tissue health and aging, and understanding and modulating stem and progenitor cell growth and remodeling kinetics in settings of disease or injury. Dr. Muschler has authorized over ten patents, including Colonyze, a quantitative automated image analysis system for assay of stem cells and progenitors.
Cells are the core resource for biological products and biomanufacturing. No new tissue is formed without cells. However, cell populations from different donors and tissues are highly variable with respect to the concentration, prevalence and the biological potential. Managing this variation is a profound challenge in the design, fabrication and quality control of cell therapies. This webinar will discuss the basic research and the development of a robotic, image-based cell picking technology to determine quantitative factors that may predict cell/colony quality.