Platelet Flow Cytometry
July 31, 2019
Matthew Linden, PhD
University of Western Australia
About the Presenter
Matthew is the Associate Professor of Haematology at The University of Western Australia, where he leads the development and delivery of haematology and cytometry education to train hospital scientists. Matthew’s research interest is in platelet biology and function. Working at the interface of the shared resource laboratory, discovery and translational research, Matthew has developed novel cytometry techniques for the measurement of blood platelets and employed these in the development of new antiplatelet therapies. He is committed to advancing cytometry through strong, sustainable shared resource laboratories and cytometry education. Matthew is an ISAC Marylou Ingram Scholar and the current President of the Australasian Cytometry Society.
Flow cytometry is a powerful and versatile tool which can be used to provide substantial phenotypic data on platelets including surface expression of functional receptors, bound ligands, expression of granule components, signal transduction, platelet-platelet aggregation or interaction of platelets with leukocytes. Quantitative assessment of these parameters may facilitate the diagnosis of inherited or acquired platelet disorders, assist in the diagnosis of diseases associated with platelet activation, or assist in the monitoring of safety and efficacy of antiplatelet therapy.
- Discuss the utility of platelet flow cytometry
- Describe the process by which platelet phenotype and function are measured
- Discuss the pre-analytical and analytical variables that can affect platelet data
Who Should Attend
Clinical and research scientists who wish to measure platelet phenotype and function.